L Methylfolate | C20H23CaN7O6 | API Manufacturer

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Product Name:
L-Methylfolate
Molecular Formula:
C20H23CaN7O6
Molecular Weight:
497.5 g/mol
CAS No.:
151533-22-1
HSN Code:
29362910
CID Code:
135564391
Shelf Life:
3 years - 20°C powder
ChemSpider ID
24534025
UNII No.
A9R10K3F2F

USP
IUPAC Names
Synonyms
MSDS
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USP of L-Methylfolate

Inadequate folate levels have been associated with specific types of anemia. Folic acid supplements are available in diverse formulations, including L-methylfolate, levomefolate, and methyltetrahydrofolate. However, L-methylfolate emerges as the most bioactive form within the body. Taking a prenatal or multivitamin with L-methylfolate is more beneficial than taking one with folic acid.

IUPAC Names of L-Methylfolate

calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate

Synonyms of L-Methylfolate

Levomefolate calcium
Calcium levomefolate
Levomefolinate calcium
L-methylfolate Calcium
Levomefolate (calcium)
L-5-mthf-ca
L-methylfolate-calcium
Levomefolate calcium
Calcium L-methylfolate
L-5-Methyltetrahydrofolate calcium
Calcium L-5-methyltetrahydrofolate
L-5-methyl tetrahydrofolic
(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid, calcium salt
(6s)-5-methyltetrahydrofolic acid calcium salt
Calcium N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
Calciuml-5-Methyltetrahydrofolate
L-5-Methyletrahydrofolate calcium
calcium (2S)-2-(4-((((6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioate
calcium (2S)-2-[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzamido]pentanedioate
L-5-MTHF calcium
calcium (6s)-5-methyltetrahydrofolate
N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt
Calcium L-5-Methyltetrahydrofolate
L-5-methyltetrahydrofolic Acid, Calcium Salt
6(S)-5-methyltetrahydrofolic Acid, Calcium Salt
(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicacid,calciumsalt
calcium (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
calcium (4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
L-Glutamic acid, N-(4-((((6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)

MSDS of L-Methylfolate

Download MSDS PDF

Hazards Identification

Classification of the substance or mixture: Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
Label elements: Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
Other hazards: This substance/mixture contains no components considered to be either persistent, bio accumulative and toxic (PBT), or very persistent and very bio accumulative (vPvB) at levels of 0.1% or higher.

Basic Physical and Chemical Properties

Physical State: Solid, powder.
Appearance: White to yellow color powder.
Odor: No data available.
Solubility in water: Sparingly soluble in water.

Exposure Controls / Personal Protection

Appropriate engineering controls: Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits.
Eye/face protection: Safety glasses; Compatible chemical-resistant gloves; Lab coat and NIOSH approved respirator, as conditions warrant.
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: NIOSH approved respirator, as conditions warrant.
Control of environmental exposure: Do not let product enter drains.

Disposal Considerations

Waste treatment methods Product: Dispose in accordance with local, state, and federal regulations.
Contaminated packaging: Dispose of as unused product.

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Description of L-Methylfolate

Folate, a vital B-vitamin inherent in various dietary sources, plays a crucial role in cellular formation, particularly in the development of healthy red blood cells. Possessing superior absorption capabilities, L-methylfolate effectively enhances folate concentrations in the bloodstream.

Application of L-Methylfolate

Treatment of Major Depressive Disorder (MDD): Used as an adjunctive treatment to enhance the efficacy of antidepressants.
Management of Folate Deficiency: Essential in treating or preventing folate deficiency, particularly in individuals with genetic polymorphisms like MTHFR mutation.
Pregnancy and Lactation: Prescribed to pregnant women to prevent neural tube defects and other fetal developmental issues.
Psychiatric Disorders: Used in managing certain psychiatric conditions like schizophrenia and bipolar disorder, where folate metabolism plays a role.
Cardiovascular Health: Helps in reducing homocysteine levels, thereby potentially lowering the risk of heart diseases.
Neurological Disorders: Applied in the treatment of neuropathies and certain neurodegenerative diseases where folate metabolism is implicated.
Used in elderly patients or those with cognitive impairments to improve brain function and memory.
Alcoholism Recovery: Assists in the recovery of chronic alcoholics, where folate deficiency is often a concern.
Cancer Adjunct Therapy: Investigated for its role in enhancing the effectiveness of certain chemotherapeutic agents.
Pediatric Use: Prescribed for children with folate metabolism disorders or specific genetic conditions affecting folate usage.

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Frequently Asked Questions on: L-Methylfolate

What is L-methylfolate?

L-methylfolate is the absorbable, active form of folate (vitamin B9) directly usable by the body.

How does it differ from folic acid?

Folic acid is naturally occuring form of folate that requires conversion in the body to L-methylfolate for use. This conversion can be inefficient in some individuals due to genetic variations.

Is L-methylfolate more effective than folic acid?

L-methylfolate is 7 times more effective than folic acid.

Is L-methylfolate directly absorbed?

Yes, L-methylfolate is the active form and can be directly absorbed by the body without conversion.

What are the forms available for L-methyl folate?

L-methylfolate supplements come in various forms like tablets, capsules, and lozenges. The specific form may not significantly impact absorption.

Why is L-methylfolate considered the more bioavailable form of folate?

L-methylfolate skips the conversion step needed for folic acid, making it readily available for use in the body.