-
Product Name:
Ferric Carboxymaltose
-
Molecular Formula:
C24H44FeO25-
-
Molecular Weight:
788.4 g/mol
-
CAS No.:
9007-72-1
-
HSN Code:
30045090
-
CID Code:
86278165
-
Shelf Life:
3 years - 20°C powder
-
DrugBank ID
DB08917
-
UNII No.
6897GXD6OE
- USP
- IUPAC Names
- Synonyms
- MSDS
USP of Ferric Carboxymaltose
- Ferric carboxymaltose’s intravenous delivery bypasses gut absorption for superior iron influx and reduced GI side effects compared to oral iron.
- Ideal for patients with oral iron intolerance/resistance or chronic kidney disease.
- Carbohydrate shell regulates iron release, reducing overload risk.
- Enables shorter infusion times compared to other intravenous iron therapies, improving treatment time and reducing infusion reaction risk
- FCM shows little anaphylactic shock or hypersensitive reaction.
- Offers increased injection safety margin over iron sucrose.
IUPAC Names of Ferric Carboxymaltose
4-[5-[3,4-dihydroxy-6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate
Synonyms of Ferric Carboxymaltose
- Ferric carboxymaltose
- Iron Dextri-Maltose
- iron carboxymaltose
- polynuclear iron (III)-hydroxide 4(R)-(poly-(1->4)-o-alpha-D-glucopyranosyl)-oxy-2(R),3(S),5(R), 6-tetrahydroxy-hexanoate
MSDS of Ferric Carboxymaltose
Download MSDS PDF- GENERAL ADVICE: Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell (show the label where possible).
- IF INHALED: When symptoms occur: Go into open air and ventilate suspected area. Seek medical attention.
- SKIN CONTACT: Remove contaminated clothing. Drench affected area with water for at least 15 minutes. Seek medical attention.
- EYE CONTACT: Rinse thoroughly with plenty of water for 15 minutes and consult a physician.
- IF SWALLOWED: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
- SUITABLE EXTINGUISHING MEDIA: Water spray, dry chemical, foam, carbon dioxide.
- SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE: Carbon oxides, nitrogen oxides (NOx), Iron oxides.
- ADVICE FOR FIREFIGHTERS: Wear self-contained breathing apparatus for firefighting if necessary.
- FIRE EXTINGUISHING MEDIA: Use fire-extinguishing media appropriate to the surrounding fire
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet. - FURTHER INFORMATION: No data available.
- APPROPRIATE ENGINEERING CONTROLS: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
- EYE/FACE PROTECTION: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- SKIN PROTECTION: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
- BODY PROTECTION: Impervious clothing, the type of protective equipment must be selected according to the concentration and amount of the amount of the dangerous substance at the specific workplace.
- EXPOSURE LIMITS: TWA: 1 STEL: 2 (mg(Fe)/m ) [United Kingdom (UK)] TWA: 1 (mg(Fe)/m) from MSHA standard. Consult local authorities for acceptable exposure limits.
- Appearance form: Powder
- Color: Brown to deep brown.
- Odour: No data available
- Solubility: Soluble in warm water.
- Molecular weight: No data available
- pH: 5.0-7.0
- Other safety information: No data available
Description of Ferric Carboxymaltose
Ferric Carboxymaltose is a unique iron replacement therapy medication with interesting scientific and chemical properties. Unlike traditional iron supplements, it’s a carbohydrate-based complex formulated with iron (III) ions. This complex gives ferric carboxymaltose a distinct lack of color and odor, making it more palatable for patients compared to iron with a metallic taste. It also lacks the hygroscopic nature (attracting moisture) of some iron salts, resulting in a stable, injectable form. Chemically, ferric carboxymaltose is a large molecule with a complex structure. It consists of a central core of ferric (Fe3+) ions surrounded by a shell of carboxymaltose molecules, a high-molecular-weight polysaccharide derived from starch.
The carboxymaltose ligands are covalently linked to the ferric ions through ester linkages, forming a stable and biocompatible complex. This unique structure allows for slow, controlled release of iron into the bloodstream, minimizing side effects often associated with iron supplements. Ferric carboxymaltose’s scientific properties and lack of unpleasant sensory qualities make it a valuable therapeutic option for iron deficiency anemia.
As a leading API manufacturer, WBCIL prioritizes strict CGMP and ISO quality control measures throughout the production process. The prolonged experience from 1962 ensures consistent potency, purity, and safety in every dose of WBCIL’s ferric carboxymaltose
Application of Ferric Carboxymaltose
Treatment of Iron Deficiency Anemia (IDA)
Administered to patients with IDA who cannot tolerate oral iron supplements or have not responded to oral iron therapy.
Often used in patients with chronic kidney disease, inflammatory bowel disease, or cancer.
Perioperative Management
Utilized to correct preoperative anemia in surgical patients, thereby reducing the need for blood transfusions and improving surgical outcomes.
Gynaecology and Obstetrics
Employed in the treatment of iron deficiency in pregnant women to support increased iron requirements and prevent maternal and fetal complications.
Gastroenterology
Administered to patients with gastrointestinal disorders such as celiac disease, Crohn’s disease, and ulcerative colitis, where oral iron absorption is impaired.
Cardiology
Used in heart failure patients to treat iron deficiency, improving symptoms and quality of life.
Nephrology
Applied in the management of anemia in patients with chronic kidney disease, particularly those undergoing dialysis, where erythropoiesis-stimulating agents are used.
Applications in medical fields
- Iron Deficiency Anemia Treatment: Used primarily for the treatment of iron deficiency anemia.
- Chronic Kidney Disease: Particularly beneficial for patients with chronic kidney disease.
- Rapid Iron Replenishment: Provides a fast and efficient method for replenishing.
- Postpartum Anemia: Helping new mothers recover iron levels quickly.
- Chronic Heart Failure: Used to manage iron deficiency in patients with chronic heart failure.
- Inflammatory Bowel Disease: Suitable for patients with inflammatory bowel disease (IBD).
Nutraceutical Uses
Iron Supplementation: Included in specialized dietary supplements aimed at individuals with specific iron needs
Enhanced Bioavailability: Offers a highly bioavailable form of iron, ensuring better absorption and efficacy
General Health and Wellbeing: Supports overall health by maintaining adequate iron levels, which are essential for numerous bodily functions.
Energy Levels: Helps boost energy levels by improving oxygen transport and reducing fatigue causedby iron deficiency.
Athletic Performance: Beneficial for athletes who require optimal iron levels for peak performanceand recovery.
Side effects:
Ferric carboxymaltose may cause various side effects if not advisably taken. Here are the key side effects:
- Nausea
- Vomiting
- Headache
- Dizziness
Suppliers of Ferric Carboxymaltose include major pharmaceutical company like West Bengal Chemical Industries Limited.
Another name for Ferric Carboxymaltose is Injectafer (in the USA) or Ferinject (in other markets).
Ferric Carboxymaltose is composed of a ferric iron complex with a carbohydrate polymer (Carboxymaltose) designed for intravenous iron supplementation.
Ferric carboxymaltose replenishes iron stores in the body, helping to treat iron deficiency anemia by increasing hemoglobin levels and improving symptoms associated with iron deficiency.
Ferric Carboxymaltose is classified as an intravenous iron replacement therapy.
Ferric Carboxymaltose is typically a dark brown, opaque solution.
