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Product Name:
Magnesium Bisglycinate
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Molecular Formula:
C4H8MgN2O4
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Molecular Weight:
172.42 g/mol
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CAS No.:
14783-68-7
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HSN Code:
29224990
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CID Code:
84645
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Shelf Life:
3 years - 20°C powder
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DrugBank ID
DB11189
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ChemSpider ID
76358
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UNII No.
IFN18A4Y6B
- USP
- IUPAC Names
- Synonyms
- MSDS
USP of Magnesium Bisglycinate
- The chelation of magnesium with glycine improves its solubility in aqueous solutions. This increased solubility facilitates its absorption from the gastrointestinal tract.
- Potential synergistic effects with glycine
- The glycine molecules act as carriers, aiding in the transport of magnesium across the intestinal epithelium leading to Improved absorption
- Reduced gastrointestinal side effects
- This chelated form of magnesium is better tolerated
IUPAC Names of Magnesium Bisglycinate
- Magnesium diglycinate
- Magnesium bis(aminoacetate)
Synonyms of Magnesium Bisglycinate
- bis(glycinato)magnesium
- magnesium bis(glycinate)
- magnesium diglycinate
- magnesium 2-aminoacetate
- Magnesium Glycinate
- Bis(glycinato-N,O)magnesium
- Magnesium diglycinate
- magnesium;2-aminoacetate
- Magnesium glycinate
- [(2-aminoacetyl)oxy]magnesio 2-aminoacetate
- magnesium2-aminoacetate
- Glycine, magnesuim salt
- Magnesium 2-Aminoacetate xH2O
- Magnesium Glycinate [WHO-DD]
- Magnesium,bis(glycinato)- (6CI,7CI,8CI)
MSDS of Magnesium Bisglycinate
Download MSDS PDF- Eye: Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.
- Skin: Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.
- Ingestion: Wash out mouth with water provided person is conscious. Call a physician. Safety Data Sheet FM157440 page 2 of 4 Most important symptoms and effects, both acute and delayed
- Hints for Physician: Symptoms
- Inhalation: Remove casualty to fresh air and keep warm and at rest. If breathing is irregular or stopped, administer artificial respiration. Call a physician.
- Hints for Physician – Treatment: Treat symptomatically.
- Precautions for safe handling
Handling advice: Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling. - Conditions for safe storage, including any incompatibilities
Storage temperature: store at 10°C – 25°C
Storage Requirements: Keep away from incompatible substances. Store in a cool, dry, well-ventilated area away from incompatible substances.
- Exposure limit values: Does not contain any substances with occupational exposure limits.
- Exposure controls
Industrial Hygiene: Mechanical exhaust required. Safety shower and eye shower. - Personal Protective Equipment
Respiratory Protection: Wear NIOSH/MSHA or European Standard EN 149 approved respirator.
Hand Protection: Wear compatible chemical-resistant gloves to prevent skin exposure.
Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.
Body Protection: Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.
Advice on Safe Handling: Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.
- Appearance Form: Powder
- Color: Light brown
- Odour: No data available
- pH of 1 % w/v suspension: 7.50 – 10.50
Description of Magnesium Bisglycinate
Magnesium bisglycinate, a well-tolerated form of magnesium, boasts unique physical and chemical properties. Unlike some magnesium supplements, it’s typically odorless and tasteless, making it easier to consume. Its texture varies depending on the formulation; it can be a fine white powder (in capsules) or compressed into tablets.
Interestingly, magnesium bisglycinate is non-hygroscopic, meaning it won’t readily absorb moisture from the air, which enhances its shelf life and stability compared to some other magnesium compounds. On a scientific level, magnesium bisglycinate is a chelate, formed when a central magnesium ion binds to two glycine molecules (the simplest amino acid). This chelation improves magnesium’s absorption within the body.
As a leading API manufacturer, WBCIL prioritizes strict CGMP and ISO quality control measures throughout the production process. The prolonged experience from 1962 ensures consistent potency, purity, and safety in every dose of WBCIL’s Magnesium Bisglycinate.
Application of Magnesium Bisglycinate
Improved Magnesium Absorption
Enhanced Absorption: Magnesium bisglycinate is chelated with glycine, which improves its solubility and facilitates better absorption in the gastrointestinal tract. This makes it an ideal choice for individuals with magnesium deficiencies or absorption issues.
Synergistic Effects with Glycine
Combined Benefits: The presence of glycine in magnesium bisglycinate not only aids in absorption but may also provide additional health benefits, such as supporting relaxation and sleep. The synergistic effects of magnesium and glycine can help in calming the nervous system and promoting overall well-being.
Better Transport Across the Intestinal Epithelium
Efficient Transport Mechanism: Glycine acts as a carrier for magnesium, aiding in its transport across the intestinal lining. This results in a more efficient and effective uptake of magnesium into the bloodstream, making magnesium bisglycinate highly bioavailable.
Reduced Gastrointestinal Side Effects
Gentle on the Stomach: Magnesium bisglycinate is known for being better tolerated by the digestive system compared to other forms of magnesium, such as magnesium oxide or citrate. It is less likely to cause common side effects like diarrhea or stomach discomfort, making it suitable for individuals with sensitive digestive systems.
Pharmaceutical Uses
- Muscle Relaxant: Used to treat muscle cramps, spasms, and conditions like fibromyalgia.
- Cardiovascular Health: Supports heart health by regulating blood pressure and maintaining normal heart rhythm.
- Neurological Health: Helps in managing conditions such as migraines, anxiety, and depression.
- Bone Health: Essential for maintaining bone density and preventing osteoporosis
- Anti-inflammatory: Possesses anti-inflammatory properties, aiding in the treatment of chronic inflammatory conditions.
- Sleep Disorders: Used to improve sleep quality and manage insomnia due to its calming effects.
Nutraceutical Uses
- Supplementation: Popular in dietary supplements for overall health and wellness.
- Athletic Performance: Enhances muscle recovery, reduces muscle soreness, and prevents cramps in athletes.
- Energy Production: Supports mitochondrial function and energy production, reducing fatigue.
- Stress Reduction: Helps in stress management by promoting relaxation and reducing cortisol levels.
- Immune Support: Strengthens immune response and enhances resistance to infections.
Magnesium Bisglycinate may cause various side effects if not advisably taken. Here are the key side effects:
- Nausea
- Stomach upset
- Diarrhea (less common with bisglycinate)
- Abdominal cramping
- Gas and bloating
- Low blood pressure (dizziness, lightheadedness)
- Allergic reactions (rare; rash, itching, swelling) Dizziness
Manufacturers of magnesium bisglycinate API in India include West Bengal chemical Industries Limited as the top magnesium bisglycinate manufacturer in India.
Magnesium bisglycinate is synthesized through the reaction of magnesium with glycine, an amino acid, often derived from both natural and synthetic sources.
Another name for magnesium bisglycinate is magnesium glycinate.
Magnesium bisglycinate is made of magnesium chelated to two molecules of glycine, forming a highly absorbable and bioavailable form of magnesium.
Magnesium bisglycinate supports various bodily functions, including muscle relaxation, nerve function, energy production, and bone health, while also being gentle on the digestive system.
Magnesium bisglycinate is typically a white or off-white powder.
The raw materials for magnesium bisglycinate include elemental magnesium and glycine.
Glycinate generally refers to a single glycine molecule chelated to a mineral, whereas bisglycinate refers to two glycine molecules chelated to a mineral, enhancing its absorption and bioavailability.
